Dose response of sodium nitrite on vasoactivity associated with HBOC-201 in a swine model of controlled hemorrhage.

نویسندگان

  • Françoise Arnaud
  • Anke H Scultetus
  • Bobby Kim
  • Ashraful Haque
  • Biswajit Saha
  • Savita Nigam
  • Paula Moon-Massat
  • Charles Auker
  • Richard McCarron
  • Daniel Freilich
چکیده

Sodium nitrite (NaNO(2)) was evaluated in a 55% EBV hemorrhage swine model to mitigate the increased blood pressure due to HBOC-201. Animals were resuscitated by three 10 ml/kg infusions of either HBOC-201 or Hextend with and without NaNO(2). All vital signs, coagulation and blood chemistry were measured for 2 hr. HBOC-201-vasoconstriction was attenuated only after the first 10.8 μmol/kg NaNO(2) infusion. Complete abolition was obtained with the highest 3 NaNO(2) dose, but side effects were observed. There was no reduction in platelet function due to NaNO(2). NaNO(2) ability to reduce HBOC-201 vasoactivity was transient and 10.8 μmol/kg NaNO(2) seems an acceptable dose for further investigation.

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منابع مشابه

The effect HBOC-201 and sodium nitrite resuscitation after uncontrolled haemorrhagic shock in swine.

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A hemoglobin-based oxygen carrier, bovine polymerized hemoglobin (HBOC-201) versus hetastarch (HEX) in a moderate severity hemorrhagic shock swine model with delayed evacuation.

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عنوان ژورنال:
  • Artificial cells, blood substitutes, and immobilization biotechnology

دوره 39 4  شماره 

صفحات  -

تاریخ انتشار 2011